Synthesis of HyperBranched Polymers with multiple reactive terminal groups by aqueous dispersion polymerization Hyperbranched polymers (HBPs) are highly branched macromolecules. In comparison with linear polymers, they have several advantages including an internal cavity and abundant functional groups with multivalent effect. HBP structures are irregular in comparison with dendrimers ones but offer advantages in terms of facile synthesis in one-pot reaction, low cost-efficient synthesis and flexible compositions.
The self-condensing vinyl polymerization (SCVP), combined with reversible addition-fragmentation chain transfer (RAFT) polymerization, allows access to HBP with relatively low dispersity, and controlled size, branching and terminal units at the periphery. HBPs synthesized via RAFT-mediated SCVP are especially interesting in the design of therapeutic carriers for targeted delivery. Indeed, the globular three dimensional structure lead to the formation of an internal cavity that can be used to encapsulate therapeutics, and the potential high density of functional groups at the periphery of HBP (taking advantage of the Z groups) can be used to introduce targeting ligands or bioresponsive components. The aim of this project is to designing cationic HBPs with different and multiple reactive terminal groups at the periphery and a controlled structure in terms of size, dispersity and DB.
A confined environment could be used to enhance the variety of terminal groups on HBP periphery and to achieve structurally defined HBP cavity. Dispersion, emulsion and microemulsions are considered to ensure compartmentalization effects. The azlactone chemistry has emerged as a powerful chemical handle for the synthesis of a wide library of functional linear polymers and materials. Therefore, the research hypotheses to reach the proposal objectives are based on a confined RAFTSCVP in aqueous dispersed media and on azlactone chemistry to both build the structurally controlled HBP cavity and introduce multiple reactive terminal groups, respectively.
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