“Preparation and study of pre-catalysts for C-C and C-Si coupling”
My PhD is part of the HYPERCAT project.
The aim of this work is the design of several mono- and bi-metallic nanoparticles supported on silica-based material for Suzuki-Miyaura cross-coupling (Pd) or hydrosilylation (Pt) as well as the rationalization of the active species in order to produce hyperactive catalytic species at very low metallic loading.
These reactions were targeted because of health, environmental and economic (HEE) issues coming from the intensive use of these scarce metals in both pharmaceuticals and silicone market. Indeed, the strict regulations of the palladium traces in active pharmaceutical ingredients (API) urge the chemical industry to found either an alternative to palladium or reduce the amount needed to obtain the same productivity. Hence, a generation of hyperactive species that might be recovered after catalysis for the targeted cross-coupling reaction could prevent a toxicity generated by the accumulation of exogenous metals not regulated by homeostasis.
The same goes for the silicon market, where platinum is often not recovered because it is trapped in the final product and even with an adsorption on charcoal, a depletion of this strategic resource is to be feared in a near future. If hyper-low and recoverable amounts of platinum could have the same activity as currently soluble platinum complexes, the shortage could be slower.
My work consists in:
- synthesis of nanoparticles with a narrow distribution
- immobilization of those on silica-based materials
- catalytic test in batch reactor to assess their catalytic parameters
- characterization before and after catalysis of the targeted catalytic materials
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